Role of Interleukin-36 in inflammatory joint diseases / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 249-259, 2023.
Article
in English
| WPRIM
| ID: wpr-982042
ABSTRACT
Interleukin (IL)-36 is a family of cytokines that belongs to the larger IL-1 superfamily. IL-36 agonist/antagonist binds to the interleukin-36 receptor involving in physiological inflammation regulation and pathogenesis of many inflammatory diseases. In inflammatory joint diseases, the expression of IL-36 changes, and some studies have initially explored the role of IL-36 in these diseases. In psoriatic arthritis, IL-36 signal mediates plasma cell and fibroblast-like synoviocyte crosstalk presenting IL-36 agonist/antagonist imbalance. In rheumatoid arthritis, IL-36 agonists induce fibroblast-like synoviocyte to produce pro-inflammatory factors, while IL-36 antagonist deficiency leads to lesion progression. In osteoarthritis, IL-36 agonists induce chondrocytes to produce catabolic enzymes and pro-inflammatory factors. This article reviews the expression and function of IL-36 in different inflammatory joint diseases to provide a reference for revealing their pathogenic mechanisms and discovering therapeutic targets.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoarthritis
/
Arthritis, Rheumatoid
/
Arthritis, Psoriatic
/
Cytokines
/
Interleukins
Limits:
Humans
Language:
English
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2023
Type:
Article
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