Ceritinib as First-line Treatment for Advanced Lung Adenocarcinoma
with COX7A2L-ALK Fusion: A Case Report and Literature Review / 中国肺癌杂志
Chinese Journal of Lung Cancer
; (12): 319-324, 2023.
Article
in Zh
| WPRIM
| ID: wpr-982162
Responsible library:
WPRO
ABSTRACT
Lung cancer is the most common in incidence and mortality worldwide. With the development of next generation sequencing (NGS) detection technology, more and more patients with rare anaplastic lymphoma kinase (ALK) fusion mutations were detected. A case of advanced lung adenocarcinoma with rare COX7A2L-ALK (C2:A20) fusion detected by NGS was reported in Peking Union Medical College Hospital, and all cases with rare ALK fusion mutations were searched from medical datebase from January 1, 2014 to March 31, 2021, to investigate the treatment of rare ALK fusion mutations with ALK inhibitors. The best response of the patient was assessed as partial response (PR) with Ceritinib treatment. By literature review, 22 cases of rare ALK fusion were reported in 19 articles. Combined with this case, 23 cases were analyzed. The objective response rate (ORR) was 82.6% (19/23) and disease control rate (DCR) was 95.7% (22/23) for rare ALK fusions patients treated with ALK inhibitors. Lung adenocarcinoma patients with rare ALK fusion could benefit from ALK inhibitors.
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Key words
Full text:
1
Index:
WPRIM
Main subject:
Oncogene Proteins, Fusion
/
Protein Kinase Inhibitors
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Adenocarcinoma of Lung
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Crizotinib
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Anaplastic Lymphoma Kinase
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Lung Neoplasms
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Lung Cancer
Year:
2023
Type:
Article