Let -7i : A key player and a promising biomarker in diseases / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
;
(12): 909-919, 2023.
Article
in English
| WPRIM
| ID: wpr-982363
ABSTRACT
MicroRNAs (miRNAs) are endogenous non-coding single-stranded small RNAs that regulate gene expression by recognizing homologous sequences and interfering with transcriptional, translational or epigenetic processes. MiRNAs are involved in a variety of disease processes, and regulate the physiological and pathological status of diseases by modulating target cell activity, migration, invasion, apoptosis, autophagy and other processes. Among them, let-7i is highly expressed in various systems, which participates in the process of tumors, cardiovascular and cerebrovascular diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases and other diseases, and plays a positive or negative regulatory role in these diseases through different signal pathways and key molecules. Moreover, it can be used as an early diagnosis and prognostic marker for a variety of diseases and become a potential therapeutic target. As a biomarker, let-7i is frequently tested in combination with other miRNAs to diagnose multiple diseases and evaluate the clinical treatment or prognosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autophagy
/
Biomarkers
/
Apoptosis
/
MicroRNAs
/
Epigenesis, Genetic
Language:
English
Journal:
Journal of Central South University(Medical Sciences)
Year:
2023
Type:
Article
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