Chromatin Remodeling Factor SMARCA5 is Essential for Hippocampal Memory Maintenance via Metabolic Pathways in Mice / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 1087-1104, 2023.
Article
in En
| WPRIM
| ID: wpr-982458
Responsible library:
WPRO
ABSTRACT
Gene transcription and new protein synthesis regulated by epigenetics play integral roles in the formation of new memories. However, as an important part of epigenetics, the function of chromatin remodeling in learning and memory has been less studied. Here, we showed that SMARCA5 (SWI/SNF related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 5), a critical chromatin remodeler, was responsible for hippocampus-dependent memory maintenance and neurogenesis. Using proteomics analysis, we found protein expression changes in the hippocampal dentate gyrus (DG) after the knockdown of SMARCA5 during contextual fear conditioning (CFC) memory maintenance in mice. Moreover, SMARCA5 was revealed to participate in CFC memory maintenance via modulating the proteins of metabolic pathways such as nucleoside diphosphate kinase-3 (NME3) and aminoacylase 1 (ACY1). This work is the first to describe the role of SMARCA5 in memory maintenance and to demonstrate the involvement of metabolic pathways regulated by SMARCA5 in learning and memory.
Key words
Full text:
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Index:
WPRIM
Main subject:
Transcription Factors
/
Chromatin
/
Chromatin Assembly and Disassembly
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Metabolic Networks and Pathways
/
Hippocampus
/
Memory
Limits:
Animals
Language:
En
Journal:
Neuroscience Bulletin
Year:
2023
Type:
Article