NETO2 promotes melanoma progression via activation of the Ca2+/CaMKII signaling pathway / 医学前沿
Frontiers of Medicine
;
(4): 263-274, 2023.
Article
in English
| WPRIM
| ID: wpr-982570
ABSTRACT
Melanoma is the most aggressive cutaneous tumor. Neuropilin and tolloid-like 2 (NETO2) is closely related to tumorigenesis. However, the functional significance of NETO2 in melanoma progression remains unclear. Herein, we found that NETO2 expression was augmented in melanoma clinical tissues and associated with poor prognosis in melanoma patients. Disrupting NETO2 expression markedly inhibited melanoma proliferation, malignant growth, migration, and invasion by downregulating the levels of calcium ions (Ca2+) and the expression of key genes involved in the calcium signaling pathway. By contrast, NETO2 overexpression had the opposite effects. Importantly, pharmacological inhibition of CaMKII/CREB activity with the CaMKII inhibitor KN93 suppressed NETO2-induced proliferation and melanoma metastasis. Overall, this study uncovered the crucial role of NETO2-mediated regulation in melanoma progression, indicating that targeting NETO2 may effectively improve melanoma treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphorylation
/
Signal Transduction
/
Cell Line, Tumor
/
Cell Proliferation
/
Calcium-Calmodulin-Dependent Protein Kinase Type 2
/
Melanoma
/
Membrane Proteins
Limits:
Humans
Language:
English
Journal:
Frontiers of Medicine
Year:
2023
Type:
Article
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