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Effect-site concentration of remifentanil for blunting hemodynamic responses to tracheal intubation using light wand during target controlled infusion-total intravenous anesthesia / 대한마취과학회지
Korean Journal of Anesthesiology ; : 398-402, 2011.
Article in English | WPRIM | ID: wpr-9826
ABSTRACT

BACKGROUND:

Transillumination using a light wand is an alternative type of laryngoscope used for tracheal intubation. There is little information available on the effect-site concentration of remifentanil required to control hemodynamic changes induced by tracheal intubation using the transillumination method during total IV anesthesia. We therefore conducted this study to determine the effect-site concentration of remifentanil blunting hemodynamic responses after tracheal intubation in patients receiving propofol anesthesia.

METHODS:

We enrolled 26 healthy adult patients (ASA physical status I-II), aged 16-67 scheduled for surgery within 2 hours. All patients received a target-controlled infusion of 4 microg/ml propofol. The effect-site target-concentration of remifentanil of 5.0 ng/ml was chosen for the first patient. We used the Dixon's up-and-down sequential allocation method for determining the next remifentanil concentration. The time required for tracheal intubation was measured as the level of intubation stimulation.

RESULTS:

The average intubation time was 13.9 +/- 9.1 seconds. From the Dixon's method, the EC50 of remifentanil blunting the hemodynamic response to tracheal intubation was 2.94 ng/ml.

CONCLUSIONS:

This study shows that effect-site concentrations of remifentanil of 2.94 ng/ml is effective in blunting sympathetic responses to tracheal intubation in 50% of patients with normal airway anatomy when combined with a target controlled infusion of propofol (4 microg/ml).
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Piperidines / Transillumination / Propofol / Laryngoscopes / Hemodynamics / Intubation / Anesthesia / Anesthesia, Intravenous / Light Limits: Adult / Aged / Humans Language: English Journal: Korean Journal of Anesthesiology Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Piperidines / Transillumination / Propofol / Laryngoscopes / Hemodynamics / Intubation / Anesthesia / Anesthesia, Intravenous / Light Limits: Adult / Aged / Humans Language: English Journal: Korean Journal of Anesthesiology Year: 2011 Type: Article