New di-spirocyclic labdane diterpenoids from the aerial parts of Leonurus japonicus / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 551-560, 2023.
Article
in English
| WPRIM
| ID: wpr-982724
ABSTRACT
Phytochemical investigation on the ethanol extract of a well-known medicinal herb Leonurus japonicus, led to the separation of 18 labdane type diterpenoids (1-18). Through comprehensive spectroscopic analyses and quantum chemical calculations, these compounds were structurally characterized as six new interesting 5,5,5-di-spirocyclic ones (1-6), two new (7 and 8) and six known (13-18) interesting 6,5,5-di-spirocyclic ones, a new rare 14,15-dinor derivative (9), and three new ones incorporating a γ-lactone unit (10-12). An in vitro neuroprotective assay in RSC96 cells revealed that compounds 7 and 12 exhibited neuroprotective activity in a concentration-dependent way, comparable to the reference drug N-acetylcysteine.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Magnetic Resonance Spectroscopy
/
Molecular Structure
/
Leonurus
/
Plant Components, Aerial
/
Diterpenes
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2023
Type:
Article
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