A study on the relationship between the expression of apoptosis-related gene and the injury time in earlier period following cerebral contusion / 法医学杂志
Journal of Forensic Medicine
;
(6): 78-80, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-982975
ABSTRACT
OBJECTIVE@#To investigate the relationship between the expressive variety of apoptosis-related gene Bcl-2, Fas and the brain injury time during earlier period after cerebral contusion.@*METHODS@#The morphologia feature of brain tissue was observed under microscopy and immunohistochemistry, image analyze technique was applied to detected the expression of Bcl-2 and Fas.@*RESULTS@#Typical apoptotic cells were seen 8 hours after cerebral contusion. The expression of apoptosis-related gene was noted after 30 minutes and keep increase subsequently. The expression of Bcl-2 reached maximum level at 4 hours after brain trauma and then declined.@*CONCLUSION@#Detecting the expression of Bcl-2 and Fas would be of valuable in the distinguishment of promortem and postmortem injury, and the estimation of brain injury time during the earlier period after cerebral contusion.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Time Factors
/
Brain
/
Brain Concussion
/
Rats, Wistar
/
Apoptosis
/
Fas Receptor
/
Proto-Oncogene Proteins c-bcl-2
/
Forensic Medicine
Limits:
Animals
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2003
Type:
Article
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