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A study of the expression of Fas after fluid percussion brain injury in rats / 法医学杂志
Journal of Forensic Medicine ; (6): 205-207, 2004.
Article in Chinese | WPRIM | ID: wpr-983049
ABSTRACT
OBJECTIVE@#To study the pathologic diagnosis and the injury time estimation in light closed encephalon injury.@*METHODS@#Mice were hurt by fluid percussion, and were killed at 15, 30 min, 1, 3 , 6, 12 h, 1, 4, 7, 14 d respectively after injury. The expression of Fas-L in the cerebral cortex, thalamus, and hippocampi was detected by immunohistochemistry and the results were assessed by image analysis system.@*RESULTS@#It is showed that the expression of Fas-L could be detected in 1 h after injury, and increased significantly in three hours, and it reached apex 12 h after injury, and decreased gradually four days after injury, and returned normal 14 days after injury.@*CONCLUSION@#This research demonstrated that Fas-L mediated apoptosis appeared not only around brain trauma but also in the brain tissue far away from the traumatic area. It indicted that the expression of Fas-L is a useful target for diagnosis of early brain injury; the regularity of Fas-L expression could be used as one of indication to date the time of brain injury.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Time Factors / Image Processing, Computer-Assisted / Brain / Brain Injuries / Immunohistochemistry / Membrane Glycoproteins / Rats, Wistar / Apoptosis / Tumor Necrosis Factors / Fas Ligand Protein Limits: Animals Language: Chinese Journal: Journal of Forensic Medicine Year: 2004 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Time Factors / Image Processing, Computer-Assisted / Brain / Brain Injuries / Immunohistochemistry / Membrane Glycoproteins / Rats, Wistar / Apoptosis / Tumor Necrosis Factors / Fas Ligand Protein Limits: Animals Language: Chinese Journal: Journal of Forensic Medicine Year: 2004 Type: Article