Observation and analysis on mutation of routine STR locus / 法医学杂志
Journal of Forensic Medicine
;
(6): 86-89, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-983078
ABSTRACT
OBJECTIVE@#To observe and analyze the characteristic of mutation at STR locus.@*METHODS@#27 mutant genes observed in 1211 paternity testing cases were checked by PAGE-silver stained and PowerPlex 16 System Kit and validated by sequencing.@*RESULTS@#Mutant genes locate on 15 loci. The pattern of mutation was accord with stepwise mutation model. The mutation ratio of male-to-female was 81 and correlated to the age of father.@*CONCLUSION@#Mutation rate is correlated to the geometric mean of the number of homogeneous repeats of locus. The higher the mean, the higher the mutation rate. These loci are not so appropriate for use in paternity testing.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paternity
/
DNA
/
Sex Factors
/
Polymerase Chain Reaction
/
Age Factors
/
Sequence Analysis, DNA
/
Tandem Repeat Sequences
/
Alleles
/
Forensic Medicine
/
Genotype
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2005
Type:
Article
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