Study on identification of aconiti by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry / 法医学杂志
Journal of Forensic Medicine
;
(6): 118-120, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-983087
ABSTRACT
OBJECTIVE@#The merhod of determination of traditional Chinese medicine of aconitum root has been established by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.@*METHODS@#With optimized matrix of 2,5-Dihydroxy- benzoic acid for herbal extract, the identification of aconitum root by MALDI-TOF-MS has been conditioned. By comparison of mass spetra of various of aconitium root, their fingerprint mass-to-charge ratios were found to perform identification. With the characteristic mass-to-charge ratios, It was shown that the mass spectrum of raw aconitum roots were obviously different from that of processed aconitum roots.@*RESULTS@#The raw radix aconiti could be differentiated from radix aconiti preparate by determination of MALDI-TOF-MS.@*CONCLUSION@#The identifical method of aconitum root by MALDI-TOF-MS is rapid, precise and sensitive, it can be used in toxicological analysis of medical tangle and illegal medical practice.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Quality Control
/
Aconitine
/
Drugs, Chinese Herbal
/
Sensitivity and Specificity
/
Technology, Pharmaceutical
/
Plant Roots
/
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
/
Aconitum
/
Ethanol
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2005
Type:
Article
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