Development of a gas chromatography-mass spectrometry method for the quantification of propofol in blood / 法医学杂志
Journal of Forensic Medicine
;
(6): 313-314, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-983211
ABSTRACT
OBJECTIVE@#A rapid and selective method has been developed for the determination of propofol in blood by gas chromatography-mass spectrometry (GC-MS).@*METHODS@#The blood was extrasted with the solution of internal standard, the extracted residue was analyzed by gas chromatography-mass spectrometry using selected-ion monitoring mode.@*RESULTS@#The linear range was 0.1-10 microg/mL. The coefficient(R2) was 0.993 1. The detection limit was 0.05 microg/mL.@*CONCLUSION@#The method is simple and rapid, offering superior sensitivity and selectivity for propofol. The method can be used successfully during clinical and forensic toxicology.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Propofol
/
Reproducibility of Results
/
Sensitivity and Specificity
/
Anesthetics, Intravenous
/
Gas Chromatography-Mass Spectrometry
Limits:
Humans
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2006
Type:
Article
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