Expression of synaptophysin in experimental diffuse brain injury / 法医学杂志
Journal of Forensic Medicine
;
(6): 8-13, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-983251
ABSTRACT
OBJECT@#To investigate the changes in the expression_level of synaptophysin following diffuse brain injury (DBI) in rats and to correlate the changes of the synaptophysin expression_level with the post injury time interval.@*METHODS@#Wister rats were used as a DBI model induced by Marmarou method. The changes of synaptophysin immunoreactivity on coronal sections of the rats sampled at different post-injury time intervals were used as a marker. The densitometry of the synaptophysin immunoreactivity was documented by imaging technique and analyzed by SPSS software.@*RESULTS@#The expression level of synaptophysin in DBI rats showed dynamic changes following DBI as well as during the repairing period.@*CONCLUSION@#The changes of synaptophysin level may be used as a marker for estimation of the post injury time interval in DBI.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Staining and Labeling
/
Synapses
/
Time Factors
/
Brain
/
Brain Injuries
/
Immunohistochemistry
/
Cerebral Cortex
/
Synaptophysin
/
Rats, Sprague-Dawley
/
Diffuse Axonal Injury
Limits:
Animals
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2007
Type:
Article
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