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Sequence-length polymorphism research of C-stretch in mitochondrial DNA hyper-variant region / 法医学杂志
Journal of Forensic Medicine ; (6): 123-126, 2007.
Article in Chinese | WPRIM | ID: wpr-983281
ABSTRACT
OBJECTIVE@#To investigate the polymorphism of C-stretch in mitochondrial DNA hyper-variant region and the values in forensic science.@*METHODS@#The gene frequency were detected in such two loci of nt16180 and nt310 by using PCR-sequencing technique with two pair of primers according to the reference.@*RESULTS@#The length of PCR products were 807 bp and 962 bp respectively. Seven genotypes in each locus were detected. AAAACCCCCTCCCC allele amounted to 87.72% of all nt16180 genotype, while AAAACCCCCCCCCCCCC was firstly reported in Han population. CCCCCCCCTCCCCCC allele amounted to 60.53% of all nt310 genotype. 15 haplotypes were detected among 114 samples. The GD value was 0.6309. The AAAACCCCCTCCCC-CCCCCCCCTCCCCCC haplotype was the most high frequency and amounted to 57.89%.@*CONCLUSION@#The obtained basic genetic data in two loci of nt16180 and nt310 of mtDNA will be useful for forensic science.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Polymorphism, Genetic / Haplotypes / DNA, Mitochondrial / China / Polymerase Chain Reaction / Sequence Analysis, DNA / DNA Primers / Alleles / Gene Frequency / Genetics, Population Limits: Humans Country/Region as subject: Asia Language: Chinese Journal: Journal of Forensic Medicine Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Polymorphism, Genetic / Haplotypes / DNA, Mitochondrial / China / Polymerase Chain Reaction / Sequence Analysis, DNA / DNA Primers / Alleles / Gene Frequency / Genetics, Population Limits: Humans Country/Region as subject: Asia Language: Chinese Journal: Journal of Forensic Medicine Year: 2007 Type: Article