The effects of heroin on intracellular free Ca2+ of rat myocardium / 法医学杂志
Journal of Forensic Medicine
;
(6): 424-427, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-983331
ABSTRACT
OBJECTIVE@#To observe the effects of heroin on intracellular free Ca2+ in rat myocardium.@*METHODS@#The effects of heroin on intracellular free Ca2+ were observed in cultured neonatal rat myocardium by measuring intracellular free Ca2+ concentration using calcium fluorescent probe Flou-3/AM and laser scanning confocal microscope.@*RESULTS@#Different doses and concentrations of heroin appeared to have different effects on intracellular free Ca2+ concentrations, with a dosage dependent short linear increase in the fluorescence intensity (i.e., Ca2+ concentration) leading to [Ca2+]i peak.@*CONCLUSION@#Heroin could affect concentrations of [Ca2+]i in myocardium and its dosage related effect needs further investigation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cells, Cultured
/
Calcium
/
Rats, Sprague-Dawley
/
Microscopy, Confocal
/
Calcium Signaling
/
Myocytes, Cardiac
/
Heroin
/
Dose-Response Relationship, Drug
/
Microscopy, Fluorescence
Limits:
Animals
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS