Changes of RyR2 mRNA expression in rats suffering from acute myocardial ischemia / 法医学杂志
Journal of Forensic Medicine
;
(6): 327-338, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-983403
ABSTRACT
OBJECTIVE@#To investigate the changes of ryanodine receptor 2 (RyR2) mRNA expression in rats suffering from acute myocardial ischemia.@*METHODS@#SD rats were divided randomly into normal control group, myocardial ischemia group and sudden death group. The models of myocardial ischemia and sudden cardiac death were induced by intraperitoneal injection of hypophysine. The changes of RyR2 mRNA expression in cardiac sarcoplasmic reticulum (SR) of rats suffering from myocardial ischemia were detected by fluorescent RT-PCR technique.@*RESULTS@#The levels of RyR2 mRNA in the myocardial ischemia group and sudden death group were significant lower than those in the control group (P<0.05).@*CONCLUSION@#Myocardial ischemia may induce down-regulation of cardiac SR RyR2 mRNA expression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sarcoplasmic Reticulum
/
RNA, Messenger
/
Random Allocation
/
Down-Regulation
/
Death, Sudden, Cardiac
/
Rats, Sprague-Dawley
/
Myocardial Ischemia
/
Ryanodine Receptor Calcium Release Channel
/
Reverse Transcriptase Polymerase Chain Reaction
/
Forensic Pathology
Limits:
Animals
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2008
Type:
Article
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