Receptor antagonist of NMDA and animal models of schizophrenia / 法医学杂志
Journal of Forensic Medicine
;
(6): 443-446, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-983523
ABSTRACT
Schizophrenia is one of the common mental diseases. Because the mechanism of the schizophrenia is significantly complicated, the cause is still unknown. N-methyl-D-aspartate receptor antagonist can simulate the positive and negative symptoms, as well as the cognitive disorder of schizophrenia. Thus it has been widely used to establish the animal models of schizophrenia. The relationship of the three blocking agents of ion channels (phencyclidine, MK-801, ketamine) and the establishment of schizophrenia animal models is reviewed in this article.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phencyclidine
/
Schizophrenia
/
Behavior, Animal
/
Brain
/
Dizocilpine Maleate
/
Receptors, N-Methyl-D-Aspartate
/
Excitatory Amino Acid Antagonists
/
Consciousness Disorders
/
Disease Models, Animal
/
Ketamine
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS