Effects of cocaine on activities of ATPase, LDH and SDH in mouse splenocytes / 法医学杂志
Journal of Forensic Medicine
;
(6): 81-83, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-983543
ABSTRACT
OBJECTIVE@#To examine the effects of cocaine on the activities of ATPase, LDH and SDH in cultured mouse splenocytes in vitro.@*METHODS@#The ATPase, LDH and SDH activities in mouse splenocytes were detected at day 7 after continuous culturing the mouse cells exposed to cocaine hydrochloride in final concentration of 10, 20 and 100 microg/mL in vitro.@*RESULTS@#The activities of ATPase, LDH and SDH in mouse splenocytes exposed to cocaine hydrochloride in final concentration of 10, 20 and 100 microg/mL were significantly decreased after continuous culturing for 7 days.@*CONCLUSION@#The present study demonstrated that cocaine could inhibit the activities of ATPase, LDH and SDH in cultured splenocytes in vitro.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spleen
/
Succinate Dehydrogenase
/
Cells, Cultured
/
Cocaine
/
Adenosine Triphosphatases
/
Dose-Response Relationship, Drug
/
L-Lactate Dehydrogenase
/
Mice, Inbred Strains
Limits:
Animals
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2010
Type:
Article
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