Effects of cocaine on activities of ATPase, LDH and SDH in mouse splenocytes / 法医学杂志
J. forensic med
; Fa yi xue za zhi;(6): 81-83, 2010.
Article
in Zh
| WPRIM
| ID: wpr-983543
Responsible library:
WPRO
ABSTRACT
OBJECTIVE@#To examine the effects of cocaine on the activities of ATPase, LDH and SDH in cultured mouse splenocytes in vitro.@*METHODS@#The ATPase, LDH and SDH activities in mouse splenocytes were detected at day 7 after continuous culturing the mouse cells exposed to cocaine hydrochloride in final concentration of 10, 20 and 100 microg/mL in vitro.@*RESULTS@#The activities of ATPase, LDH and SDH in mouse splenocytes exposed to cocaine hydrochloride in final concentration of 10, 20 and 100 microg/mL were significantly decreased after continuous culturing for 7 days.@*CONCLUSION@#The present study demonstrated that cocaine could inhibit the activities of ATPase, LDH and SDH in cultured splenocytes in vitro.
Full text:
1
Index:
WPRIM
Main subject:
Spleen
/
Succinate Dehydrogenase
/
Cells, Cultured
/
Cocaine
/
Adenosine Triphosphatases
/
Dose-Response Relationship, Drug
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L-Lactate Dehydrogenase
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Mice, Inbred Strains
Limits:
Animals
Language:
Zh
Journal:
Fa yi xue za zhi
/
J. forensic med
Year:
2010
Type:
Article