Postmortem genetic testing in sudden cardiac death due to ion channelopathies / 法医学杂志
Journal of Forensic Medicine
;
(6): 120-127, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-983553
ABSTRACT
Sudden cardiac death accounts for majority of deaths in human. Evident cardiac lesions that may explain the cause of death can be detected in comprehensive postmortem investigation in most sudden cardiac death. However, no cardiac morphological abnormality is found in a considerable number of cases although the death is highly suspected from cardiac anomaly. With the advances in the modern molecular biology techniques, it has been discovered that many of these sudden deaths are caused by congenital ion channelopathies in myocardial cell, i.e., Brugada syndrome, long QT syndrome, catecholaminergic polymorphic ventricular tachycardia, and short QT syndrome, etc. This article presents the molecular genetics, electrocardiographic abnormalities, clinical manifestations, and mechanisms leading to sudden cardiac death with emphasis on the role of postmortem genetic testing in certification of cause of death. It may provide helpful information in investigating sudden cardiac death due to ion channelopathies in medico-legal practice.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arrhythmias, Cardiac
/
Autopsy
/
Long QT Syndrome
/
Genetic Testing
/
Cause of Death
/
Death, Sudden, Cardiac
/
Tachycardia, Ventricular
/
Forensic Pathology
/
Electrocardiography
/
Brugada Syndrome
Limits:
Humans
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2010
Type:
Article
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