Relationship between cholecystokinin gene -45C/T polymorphism and schizophrenia and its application in forensic medicine / 法医学杂志
Journal of Forensic Medicine
;
(6): 22-24, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-983619
ABSTRACT
OBJECTIVE@#To investigate the polymorphism of cholecystokinin (CCK) gene -45C/T of schizophrenia and its application in forensic medicine.@*METHODS@#Bidirectional allele specific PCR was used to detect CCK gene -45C/T polymorphisms in 207 schizophrenic patients (case group) and 202 healthy individuals (control group) of the Han population in northern China. The chi2 test was used to identify Hardy-Weinberg equilibrium of the genotype distribution in control group. The differences of genotype and allele frequencies distributions were compared between two groups.@*RESULTS@#Distributions of the genotype frequencies satisfied the law of Hardy-Weinberg equilibrium in control group. The differences between genotypic frequencies and allele frequencies were not statistical significance in case group and control groups (P > 0.05). Gender-stratified analysis showed that frequency of allele T in female case group was statistically higher than that in female control group (P = 0.044).@*CONCLUSION@#CCK gene -45C/T locus T allele may be positively associated with schizophrenia in female population and useful in schizophrenia identification.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Schizophrenia
/
Forensic Psychiatry
/
Cholecystokinin
/
Case-Control Studies
/
China
/
Polymerase Chain Reaction
/
Sequence Analysis, DNA
/
Genetic Predisposition to Disease
/
Asian People
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2011
Type:
Article
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