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Application of liquid chromatography-high resolution mass spectrometry in toxicological screening / 法医学杂志
Journal of Forensic Medicine ; (6): 376-381, 2011.
Article in Chinese | WPRIM | ID: wpr-983686
ABSTRACT
Due to the diversity of toxicologically relevant substances, the uncertainty of target compounds and the specificity of samples, toxicological screening techniques have always been valued by the forensic toxicologists. Depending on its powerful separation ability, superhigh resolution and accurate mass measurement, combined with the two levels spectrum database matching and abundance ratio of isotope ion, the liquid chromatography-high resolution mass spectrometry (LC-HRMS) analyzers have increasingly advantage in screening and identification of chemical compound. This review focuses on the applications of LC-HRMS in screening and identification of drug-of-abuse, prescription drugs, pesticide and stimulant. The prospect of LC-HRMS in forensic toxicology analysis is also included.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pesticides / Pesticide Residues / Substance Abuse Detection / Central Nervous System Agents / Chromatography, Liquid / Sensitivity and Specificity / Toxicity Tests / Doping in Sports / Tandem Mass Spectrometry / Forensic Toxicology Limits: Humans Language: Chinese Journal: Journal of Forensic Medicine Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pesticides / Pesticide Residues / Substance Abuse Detection / Central Nervous System Agents / Chromatography, Liquid / Sensitivity and Specificity / Toxicity Tests / Doping in Sports / Tandem Mass Spectrometry / Forensic Toxicology Limits: Humans Language: Chinese Journal: Journal of Forensic Medicine Year: 2011 Type: Article