Association and its forensic significance between COMT gene and schizophrenia / 法医学杂志
Journal of Forensic Medicine
;
(6): 299-304, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-983753
ABSTRACT
Catechol-O-methyltransferase (COMT) gene encodes catechol-O-methyltransferase, the variant of this gene may affect the expression and metabolic activity of COMT. As the result of the changes of the effective concentration of the catecholamine neurotransmitter in the central nervous system, central nervous system dysfunctions associated with schizophrenia. This review summarizes genetic polymorphism and diversity of COMT gene. It also elaborates the relation between SNP and haplotype of COMT gene and three aspects, which including schizophrenia, attacking and violent tendency, and the frontal cognitive function of the schizophreniac. The correlativity study between genetic variation of the COMT gene and schizophrenia in patients with attacking and violent tendency may be helpful for the assessment of forensic psychiatry.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Schizophrenia
/
Genetic Variation
/
Violence
/
Haplotypes
/
Brain
/
Dopamine
/
Catechol O-Methyltransferase
/
Gene Expression
/
Polymerase Chain Reaction
Limits:
Humans
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2012
Type:
Article
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