Relationship between genetic polymorphisms of 3 SNP loci in 5-HTT gene and paranoid schizophrenia / 法医学杂志
Journal of Forensic Medicine
;
(6): 418-421, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-983770
ABSTRACT
OBJECTIVE@#To investigate the population genetic data of 3 SNP loci (rs25533, rs34388196 and rs1042173) of 5-hydroxytryptamine transporter (5-HTT) gene and the association with paranoid schizophrenia.@*METHODS@#Three SNP loci of 5-HTT gene were examined in 132 paranoid schizophrenia patients and 150 unrelated healthy individuals of Northern Chinese Han population by PCR-RFLP technique. The Hardy-Weinberg equilibrium test was performed using the chi-square test and the data of haplotype frequency and population genetics parameters were statistically analyzed.@*RESULTS@#Among these three SNP loci, four haplotypes were obtained. There were no statistically significant differences between the patient group and the control group (P > 0.05). The DP values of the 3 SNP loci were 0.276, 0.502 and 0.502. The PIC of them were 0.151, 0.281 and 0.281. The PE of them were 0.014, 0.072 and 0.072.@*CONCLUSION@#The three SNP loci and four haplotypes of 5-HTT gene have no association with paranoid schizophrenia, while the polymorphism still have high potential application in forensic practice.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Schizophrenia, Paranoid
/
Haplotypes
/
Case-Control Studies
/
Polymerase Chain Reaction
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Asian People
/
Serotonin Plasma Membrane Transport Proteins
/
Gene Frequency
/
Genotype
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2012
Type:
Article
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