Expression of GAP-43 in midbrain ventral tegmental area of morphine withdrawal rats / 法医学杂志
Journal of Forensic Medicine
;
(6): 330-336, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-983844
ABSTRACT
OBJECTIVE@#To observe the protein expression of growth associated protein-43 (GAP-43) in midbrain ventral tegmental area in morphine withdrawal rats at different time, and to evaluate the effect of GAP-43 on morphine withdrawal memory.@*METHODS@#Rat models of morphine dependent 1 week, 2 weeks and 4 weeks were established by morphine hydrochloride intraperitoneal injection with increasing doses to establish natural withdrawal. The protein expression of GAP-43 in midbrain ventral tegmental area was observed by immunohistochemical staining and the results were analyzed by Image-Pro Plus 5.1 image analysis system.@*RESULTS@#With prolongation of dependent time, the expression of GAP-43 was decreased then increased in midbrain ventral tegmental area.@*CONCLUSION@#GAP-43 could play a role in morphine withdrawal memory in midbrain ventral tegmental area.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Substance Withdrawal Syndrome
/
Time Factors
/
Behavior, Animal
/
Mesencephalon
/
Immunohistochemistry
/
Rats, Sprague-Dawley
/
Ventral Tegmental Area
/
GAP-43 Protein
/
Disease Models, Animal
/
Morphine
Limits:
Animals
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS