Expression of monocyte chemotactic protein-1 and its receptor in sudden coronary death / 法医学杂志
Journal of Forensic Medicine
;
(6): 413-418, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-983938
ABSTRACT
OBJECTIVE@#To investigate the expression of monocyte chemotactic protein-1 (MCP-1) and its receptor CC chemokine receptor-2 (CCR-2) in coronary atherosclerosis plaques between sidden coronary death (SCD) and non-SCD. Methods The expression levels of MCP-1 and CCR-2 in SCD group, coronary atherosclerosis group (non-SCD), control group (normal coronary artery) were detected by immunohistochemistry.@*RESULTS@#Positive rates of MCP-1 among the three groups were 78%, 47%, and 0%, respectively, with significant expressing differences between each two groups (P<0.05). Positive rates of CCR-2 among three groups were 72%, 47%, and 0%, respectively, with significant expressing differences between the SCD group and coronary atherosclerosis group as well as between the SCD group and control group (P<0.05), but with no significant expressing difference between coronary atherosclerosis group and control group (P>0.05).@*CONCLUSION@#Overexpression of MCP-1 and CCR-2 in coronary atherosclerotic plaques is closely correlated with SCD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Coronary Artery Disease
/
Immunohistochemistry
/
Death, Sudden, Cardiac
/
Chemokine CCL2
/
Receptors, CCR2
Limits:
Humans
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2014
Type:
Article
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