Diagnostic Significance of BAT in Anaphylaxis to Non-ionic Contrast Media / 法医学杂志
Journal of Forensic Medicine
;
(6): 188-190, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-983985
ABSTRACT
OBJECTIVE@#To investigate the diagnostic significance of basophil activation test (BAT) in anaphylaxis to non-ionic contrast media through testing the content of CD63, mast cell-carboxypeptidase A3 (MC-CPA3), and terminal complement complex SC5b-9 of the individuals by testing their levels in the normal immune group and the anaphylaxis groups to β-lactam drugs and non -ionic contrast media.@*METHODS@#The CD63 expression of basophilic granulocyte in blood was detected by flow cytometry. The levels of MC-CPA3 in blood serum and SC5b-9 in blood plasma were detected by ELISA.@*RESULTS@#The CD63 expression of basophilic granulocyte in blood, the levels of MC-CPA3 and SC5b-9 of anaphylaxis to non-ionic contrast media and β-lactam drugs were significantly higher than that in normal immune group (P < 0.05).@*CONCLUSION@#There is activation of basophilic granulocytes, mast cells and complement system in anaphylaxis to non-ionic contrast media. BAT can be used to diagnose the anaphylaxis to non-ionic contrast media.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Basophils
/
Complement Membrane Attack Complex
/
Contrast Media
/
Carboxypeptidases A
/
Tetraspanin 30
/
Flow Cytometry
/
Granulocytes
/
Anaphylaxis
/
Mast Cells
Limits:
Humans
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS