Progress on Correlation between the Expression of CDK5 and Brain Injury Time / 法医学杂志
Journal of Forensic Medicine
; (6): 58-60, 2016.
Article
in Zh
| WPRIM
| ID: wpr-984044
Responsible library:
WPRO
ABSTRACT
Cyclin-dependent kinase 5 (CDK5) is a member of cyclin-dependent kinase family, which does not directly regulate cell cycle. Through phosphorylation of target protein, CDK5 plays an irreplaceable role in the development, reparation and degeneration of neurons. Brain injury refers to the organic injury of brain tissue caused by external force hit on the head. Owing to the stress and repair system activated by our body itself after injury, various proteins and enzymes of the brain tissues are changed quantitatively, which can be used as indicators for estimating the time of injury. This review summarizes the progress on the distribution, the activity mechanism and the physiological effects of CDK5 after brain injury and its corresponding potential served as a marker for brain injury determination.
Full text:
1
Index:
WPRIM
Main subject:
Phosphorylation
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Time Factors
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Brain
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Brain Injuries
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Neuroprotective Agents
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Cyclin-Dependent Kinase 5
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Nerve Tissue Proteins
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Neurons
Language:
Zh
Journal:
Journal of Forensic Medicine
Year:
2016
Type:
Article