Incidence and clinical characteristics of engraftment syndrome after syngeneic hematopoietic stem cell transplantation in patients with hematological diseases / 中华血液学杂志
Chinese Journal of Hematology
;
(12): 289-294, 2023.
Article
in Chinese
| WPRIM
| ID: wpr-984617
ABSTRACT
Objective:
To explore the incidence and clinical characteristics of engraftment syndrome (ES) after syngeneic hematopoietic stem cell transplantation (syn-HSCT) in patients with hematological diseases.Methods:
The clinical data of 21 patients who received syn-HSCT at People's Hospital of Peking University from January 1994 to May 2018 were retrospectively analyzed.Results:
Seven (33.3% ) of 21 patients developed ES. The onset of ES symptoms occurred at a median of 8 (range 5-13) days after HSCT, and the diagnosis of ES occurred at a median of 10 (range 7-14) days after HSCT. Steroids were administered immediately after the diagnosis of ES, the median time of symptom continuance was 2 (range 1-5) days, and all patients showed complete resolution of ES symptoms. In the multivariate analysis, patients with acute myeloid leukemia and faster neutrophil reconstitution were the risk factors for ES (HR=15.298, 95% CI 1.486-157.501, P=0.022, and HR=17.459, 95% CI 1.776-171.687, P=0.014) . Meanwhile, there was no significant difference in the overall survival and disease-free survival between patients with ES and those without ES.Conclusion:
A high incidence of ES was observed in syn-HSCT recipients. Moreover, the prognosis of ES was excellent.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Incidence
/
Retrospective Studies
/
Hematopoietic Stem Cell Transplantation
/
Graft vs Host Disease
/
Hematologic Diseases
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Hematology
Year:
2023
Type:
Article
Similar
MEDLINE
...
LILACS
LIS