The Role of Segmental Analysis of Clonazepam in Hair in Drug Facilitated Cases / 法医学杂志
Journal of Forensic Medicine
;
(6): 252-257, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-984887
ABSTRACT
OBJECTIVES@#To infer the frequency of dosage and medication history investigate of the victims in drug facilitated cases by the segmental analysis of clonazepam in hair.@*METHODS@#Freezing milling under liquid nitrogen environment combined with ultrasonic bath was used as sample pretreatment in this study, and liquid chromatography-tandem mass spectrometry was used for the segmental analysis of the hair samples collected from 6 victims in different cases. The concentrations of clonazepam and 7-aminoclonazepam were detected in each hair section.@*RESULTS@#Clonazepam and its metabolite 7-aminoclonazepam were detected in parts of hair sections from the 6 victims. The occurrence time of drug peak concentration was consistent with the intake timing provided by victims.@*CONCLUSIONS@#Segmental analysis of hair can provide the information of frequency of dosage and intake timing, which shows an unique evidential value in drug facilitated crimes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Mass Spectrometry
/
Ultrasonics
/
Substance Abuse Detection
/
Chromatography, Liquid
/
Clonazepam
/
Crime
/
Spectrometry, Mass, Electrospray Ionization
/
Forensic Toxicology
/
Forensic Medicine
/
Hair
Limits:
Adult
/
Humans
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2017
Type:
Article
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