Metabolic Characteristics of Lethal Bradycardia Induced by Myocardial Ischemia / 法医学杂志
Journal of Forensic Medicine
;
(6): 11-16, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-984899
ABSTRACT
OBJECTIVES@#To explore the metabolic characteristics of lethal bradycardia induced by myocardial ischemia in rat's serum.@*METHODS@#A rat myocardial ischemia-bradycardia-sudden cardiac death (MI-B-SCD) model was established, which was compared with the sham-operation group. The metabolic profile of postmortem serum was analyzed by gas chromatography-mass spectrometry (GC-MS), coupled with the analysis of serum metabolic characteristics using metabolomics strategies.@*RESULTS@#The serum metabolic profiles were significantly different between the MI-B-SCD rats and the control rats. Compared to the control rats, the MI-B-SCD rats had significantly higher levels of lysine, ornithine, purine, serine, alanine, urea and lactic acid; and significantly lower levels of succinate, hexadecanoic acid, 2-ketoadipic acid, glyceraldehyde, hexendioic acid and octanedioic acid in the serum. There were some correlations among different metabolites.@*CONCLUSIONS@#There is obvious metabolic alterations in the serum of MI-B-SCD rat. Both lysine and purine have a high value in diagnosing MI-B-SCD. The results are expected to provide references for forensic and clinical applications of prevention and control of sudden cardiac death.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Purines
/
Coronary Artery Disease
/
Bradycardia
/
Death, Sudden, Cardiac
/
Myocardial Ischemia
/
Disease Models, Animal
/
Metabolomics
/
Lysine
/
Gas Chromatography-Mass Spectrometry
Limits:
Animals
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2017
Type:
Article
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