Identification of New Designer Benzodiazepine Diclazepam in Drug Facilitated Sexual Assault / 法医学杂志
Journal of Forensic Medicine
;
(6): 248-252, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-984931
ABSTRACT
OBJECTIVES@#To identify the new designer drugs which are totally unknown and not in the routine testing list by the technologies such as high-resolution mass spectrometry in drug facilitated sexual assault, in order to solve the problem in actual cases.@*METHODS@#The milky fluid from an actual case was extracted and analyzed using LC-QE, ¹H-NMR and GC-MS, respectively. The accurate masses and cluster ions isotope patterns of unknown compound were obtained by LC-QE. The molecular formula was confirmed as C₁₆H₁₂C₂N₂O based on the protons number of ¹H-NMR. The isomers diclazepam and 4-chlorodiazepam were separated and detected with GC-MS.@*RESULTS@#The new designer benzodiazepine as diclazepam in the milky fluid was identified. The results provided direct evidence for the investigation and qualitative analysis of such cases.@*CONCLUSIONS@#The combined application of various methods, including LC-QE, ¹H-NMR and GC-MS, can be used to detect unknown new psychoactive substances.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sex Offenses
/
Mass Spectrometry
/
Toxicology
/
Benzodiazepines
/
Benzodiazepinones
/
Designer Drugs
/
Substance Abuse Detection
/
Chromatography, Liquid
/
Gas Chromatography-Mass Spectrometry
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Forensic Medicine
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS