Constructions and advances of animal models of Pseudomonas aeruginosa infection / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 929-934, 2023.
Article
in Chinese
| WPRIM
| ID: wpr-985498
ABSTRACT
Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogenic bacterium with complex pathogenesis and drug resistance mechanisms. It has high morbidity and mortality and can cause acute and chronic infections in immunocompromised individuals, with lung infections, wound infections, and bloodstream infections being the most common. The animal infection model of P. aeruginosa is of great value for in-depth research on the pathogenicity, drug resistance, and therapeutic measures of P. aeruginosa by simulating the pathways of human bacterial infections. This article firstly summarizes the selection, anesthesia, and disposal of experimental animals in the construction of animal models of P. aeruginosa infection, and then reviews the methods of construction, model evaluation, and applications of animal models of P. aeruginosa pulmonary infection, wound infection, and bloodstream infection, in order to provide a reference for scientific research related to P. aeruginosa infectious diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pseudomonas aeruginosa
/
Pseudomonas Infections
/
Virulence
/
Models, Animal
/
Disease Models, Animal
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Preventive Medicine
Year:
2023
Type:
Article
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