Application of mixture analysis methods in association between metals mixture exposure and DNA oxidative damage / 中华预防医学杂志
Chinese Journal of Preventive Medicine
;
(12): 1026-1031, 2023.
Article
in Chinese
| WPRIM
| ID: wpr-985514
ABSTRACT
Objectives:
To study the association between metals mixture exposure and DNA oxidative damage using mixture analysis methods, and to explore the most significant exposure factors that cause DNA oxidative damage.Methods:
Workers from steel enterprises were recruited in Shandong Province. Urinary metals were measured by using the inductively coupled plasma mass spectrometry method. The level of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) was determined by using the ultra-high performance liquid chromatography-mass spectrometry method. Bayesian kernel machine regression (BKMR), elastic net regression and quantile g-computation regression were used to analyze the association between urinary metals and urinary 8-OHdG.Results:
A total of 768 subjects aged (36.15±7.40) years old were included in the study. BKMR, elastic net regression and quantile g-computation all revealed an overall positive association between the mixture concentration and increased urinary 8-OHdG. The quantile g-computation results showed that with a 25% increase in metal mixtures, the urinary 8-OHdG level increased by 77.60%. The elastic net regression showed that with a 25% increase in exposure risk score, the urinary 8-OHdG level increased by 26%. The BKMR summarized the contribution of individual exposures to the response, and selenium, zinc, and nickel were significant contributors to the urinary 8-OHdG elevation.Conclusion:
Exposure to mixed metals causes elevated levels of DNA oxidative damage, and selenium, zinc, and nickel are significant exposure factors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Selenium
/
Zinc
/
DNA Damage
/
Bayes Theorem
/
Oxidative Stress
/
8-Hydroxy-2'-Deoxyguanosine
/
Metals
/
Nickel
Limits:
Adult
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Preventive Medicine
Year:
2023
Type:
Article
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