Quantitative Assessment of Synovial Vascularity Using Contrast-Enhanced Power Doppler Ultrasonography: Correlation with Histologic Findings and MR Imaging Findings in Arthritic Rabbit Knee Model
Korean Journal of Radiology
;
: 45-53, 2008.
Article
in English
| WPRIM
| ID: wpr-98578
ABSTRACT
OBJECTIVE:
To validate contrast-enhanced power Doppler ultrasonography (PD US) for the evaluation of synovial vascularity in an arthritic rabbit knee model in correlation with MR and histological findings. MATERIALS ANDMETHODS:
Power Doppler ultrasonography was performed for carrageenin-induced arthritic left knee and control right knee of 13 rabbits, first without and then with sonic contrast agent enhancement (Levovist, Schering, Berlin Germany), followed by gadolinium-enhanced MR imaging. Synovial vascularity was quantitatively assessed by calculating the color pixel area in power Doppler sonography using a computer-aided image analysis program and by grading the enhancement on MR images grade 1, enhancement of knee joint is less than one-third of the area; grade 2, one-third to two-thirds enhancement; and grade 3, more than two-thirds enhancement. Microvessel density (MVD) was measured on slides stained immunohistochemically for CD31 antigen for histological assessment.RESULTS:
The mean area of color pixels in PD US changed from 4.37 to 16.42 mm2 in the arthritic knee after enhancement (p 0.05).CONCLUSION:
Sonic contrast-enhanced PD US improves the visualization of synovial vascularity and allows quantitative measurement in experimentally induced rabbit arthritic knees.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polysaccharides
/
Synovial Membrane
/
Image Processing, Computer-Assisted
/
Immunohistochemistry
/
Magnetic Resonance Imaging
/
Ultrasonography, Doppler
/
Statistics, Nonparametric
/
Contrast Media
/
Gadolinium DTPA
/
Osteoarthritis, Knee
Type of study:
Diagnostic study
Limits:
Animals
Language:
English
Journal:
Korean Journal of Radiology
Year:
2008
Type:
Article
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