Correlation between High Resolution Dynamic MR Features and Prognostic Factors in Breast Cancer
Korean Journal of Radiology
;
: 10-18, 2008.
Article
in English
| WPRIM
| ID: wpr-98582
ABSTRACT
OBJECTIVE:
To correlate high resolution dynamic MR features with prognostic factors in breast cancer. MATERIALS ANDMETHODS:
One hundred and ninety-four women with invasive ductal carcinomas underwent dynamic MR imaging using T1-weighted three-dimensional fast low-angle shot (3D-FLASH) sequence within two weeks prior to surgery. Morphological and kinetic MR features were determined based on the breast imaging and reporting data system (BI-RADS) MR imaging lexicon. Histological specimens were analyzed for tumor size, axillary lymph node status, histological grade, expression of estrogen receptor (ER), expression of progesterone receptor (PR), and expression of p53, c-erbB-2, and Ki-67. Correlations between the MR features and prognostic factors were determined using the Pearson chi-square test, linear-by-linear association, and logistic regression analysis.RESULTS:
By multivariate analysis, a spiculated margin was a significant, independent predictor of a lower histological grade (p < 0.001), and lower expression of Ki-67 (p = 0.007). Rim enhancement was significant, independent predictor of a higher histological grade (p < 0.001), negative expression of ER (p = 0.001), negative expression of PR (p < 0.001) and a larger tumor size (p = 0.006). A washout curve may predict a higher level of Ki-67 (p = 0.05). Most of the parameters of the initial enhancement phase cannot predict the status of the prognostic factors. Only the enhancement ratio may predict a larger tumor size (p = 0.05).CONCLUSION:
Of the BI-RADS-MR features, a spiculated margin may predict favorable prognosis, whereas rim enhancement or washout may predict unfavorable prognosis of breast cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Image Processing, Computer-Assisted
/
Breast Neoplasms
/
Magnetic Resonance Imaging
/
Chi-Square Distribution
/
Logistic Models
/
Retrospective Studies
/
Contrast Media
/
Gadolinium DTPA
/
Carcinoma, Ductal
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
Language:
English
Journal:
Korean Journal of Radiology
Year:
2008
Type:
Article
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