Efficacy evaluation of novel oral anticoagulants in patients with cirrhosis accompanied with portal vein thrombosis: a meta-analysis / 中华肝脏病杂志
Chinese Journal of Hepatology
;
(12): 614-620, 2023.
Article
in Chinese
| WPRIM
| ID: wpr-986179
ABSTRACT
Objective:
To analyze the safety and efficacy of using novel oral anticoagulants (rivaroxaban and others) in patients with cirrhosis accompanied with portal vein thrombosis (PVT).Methods:
Clinical research literature published from the establishment of the database to June 20, 2021, was retrieved from PubMed, Web of Science, CNKI, Wanfang, and Weipu databases by combining subject terms and free words. RevMan software was used for the random group meta-analysis model.Results:
In terms of PVT recanalization, the novel oral anticoagulants (such as low molecular weight heparin and others) had a higher recanalization rate than traditional anticoagulants (OR = 13.75, 95%CI 3.58-52.9, P = 0.000 1). In terms of bleeding, the novel oral anticoagulants did not increase the risk of bleeding compared with traditional anticoagulants (OR = 2.42, 95%CI 0.62-9.41, P = 0.20).Conclusion:
The novel oral anticoagulant drugs are superior to traditional anticoagulants in terms of the occurrence of PVT recanalization; however, there is no statistically significant difference in terms of the occurrence of bleeding between the two groups.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Portal Vein
/
Treatment Outcome
/
Venous Thrombosis
/
Hemorrhage
/
Liver Cirrhosis
/
Anticoagulants
Type of study:
Systematic reviews
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2023
Type:
Article
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