Optimization of perioperative treatment strategies for locally advanced esophageal squamous cell carcinoma from the perspective of tumor heterogeneity / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 334-338, 2023.
Article
in Chinese
| WPRIM
| ID: wpr-986795
ABSTRACT
Recent advances in multimodality treatment offer excellent opportunities to rethink the paradigm of perioperative management for locally advanced esophageal squamous cell carcinoma. One treatment clearly doesn't fit all in terms of a broad disease spectrum. Individualized treatment of local control of bulky primary tumor burden (advanced T stage) or systemic control of nodal metastatic tumor burden (advanced N stage) is essential. Given that clinically applicable predictive biomarkers are still awaited, therapy selection guided by diverse phenotypes of tumor burden (T vs. N) is promising. Potential challenges regarding the use of immunotherapy may also boost this novel strategy in the future.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Esophageal Neoplasms
/
Carcinoma, Squamous Cell
/
Combined Modality Therapy
/
Esophageal Squamous Cell Carcinoma
/
Immunotherapy
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2023
Type:
Article
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