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Molecular mechanism and treatment strategy of colorectal cancer peritoneal metastasis / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery ; (12): 423-428, 2023.
Article in Chinese | WPRIM | ID: wpr-986809
ABSTRACT
Peritoneal metastatic colorectal cancer (pmCRC) is common and has been considered as the terminal stage. The theory of "seed and soil" and "oligometastasis" are the acknowledged hypotheses of pathogenesis of pmCRC. In recent years, the molecular mechanism related to pmCRC has been deeply researched. We realize that the formation of peritoneal metastasis, from detachment of cells from primary tumor to mesothelial adhesion and invasion, depends on the interplay of multiple molecules. Various components of tumor microenvironment also work as regulators in this process. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have been widely used in clinical practice as an established treatment for pmCRC. Besides systemic chemotherapy, targeted and immunotherapeutic drugs are also increasingly used to improve prognosis. This article reviews the molecular mechanisms and treatment strategies related to pmCRC.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Peritoneal Neoplasms / Prognosis / Rectal Neoplasms / Colorectal Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Survival Rate / Colonic Neoplasms / Combined Modality Therapy / Tumor Microenvironment / Cytoreduction Surgical Procedures Limits: Humans Language: Chinese Journal: Chinese Journal of Gastrointestinal Surgery Year: 2023 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Peritoneal Neoplasms / Prognosis / Rectal Neoplasms / Colorectal Neoplasms / Antineoplastic Combined Chemotherapy Protocols / Survival Rate / Colonic Neoplasms / Combined Modality Therapy / Tumor Microenvironment / Cytoreduction Surgical Procedures Limits: Humans Language: Chinese Journal: Chinese Journal of Gastrointestinal Surgery Year: 2023 Type: Article