Recalibrated scales: The use of low-dose Isotretinoin in a case of Epidermolytic Ichthyosis-NPS1 in a Filipino child
Acta Medica Philippina
;
: 592-596, 2021.
Article
in English
| WPRIM
| ID: wpr-987813
ABSTRACT
@#Epidermolytic Ichthyosis (EI) is a rare non-syndromic keratinopathic ichthyosis without definitive treatment. This is a case of EI in a 5-year-old Filipino female who presented with hyperkeratotic scales sparing the palms and soles. Histopathology revealed epidermolytic hyperkeratosis. A trial of treatment with isotretinoin 0.3 mg/kg/day, together with keratolytic agents, urea lotion and lactic acid lotion, resulted in a marked decrease in the thickness of the scales and odor. Interestingly, rebound effects were noted at 0.6 mg/kg/day. Taking into account that EI presents with more skin fragility compared to non-EHK ichthyosis, the authors surmise that there may be a smaller treatment window for patients with EI, which is notably lower than recommended for ichthyosis in general.
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Index:
WPRIM (Western Pacific)
Main subject:
Isotretinoin
/
Hyperkeratosis, Epidermolytic
Language:
English
Journal:
Acta Medica Philippina
Year:
2021
Type:
Article
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