Research Progress on Relation Between CD47 and Immunotherapy on Lymphoma / 肿瘤防治研究
Cancer Research on Prevention and Treatment
;
(12): 799-803, 2021.
Article
in Chinese
| WPRIM
| ID: wpr-988451
ABSTRACT
CD47 is a member of the immunoglobulin superfamily. It is expressed on various cells and tissues of human, but it is more expressed on tumor cells, especially in various hematopoietic tumors. The combination of CD47 expressed on tumor cells with signal regulator protein α (SIRPα) on macrophages inhibits the phagocytosis of tumors by macrophages. The reaction can lead to tumor immune escape. CD47 has become a new hot spot in tumor research. This article reviews the correlation between the structure and expression of CD47, CD47-SIRPα, CD47-targeting antibody drugs and lymphoma immunotherapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Cancer Research on Prevention and Treatment
Year:
2021
Type:
Article
Similar
MEDLINE
...
LILACS
LIS