Progress on the mechanism of resistance of Streptococcus pneumoniae to β-lactam antibiotics and vaccine immunoprophylaxis / 国际儿科学杂志
International Journal of Pediatrics
;
(6): 42-46, 2023.
Article
in Chinese
| WPRIM
| ID: wpr-989034
ABSTRACT
Streptococcus pneumoniae(SP)is one of the common pathogens of respiratory tract infection in children, which can evolve into severe pneumonia and necrotizing pneumonia in case of severe infection.β-lactam antibiotics are the first-line treatment for SP.The resistance mechanism of SP to β-lactam antibiotics is mainly PBPs gene mutation, followed by mutations related to non-PBPs genes such as MurM, CpoA, TEM, CiaH/CiaR-TCSS and StkP-PhpP signal conjugations.Antibiotic selection pressure and vaccine-induced serotype substitution may influence SP resistance.Serotypes 19F and 19A have high resistance to β-lactam antibiotics, and promotion of PCV13 may be more beneficial than other SP vaccines in preventing SP infection in children.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Pediatrics
Year:
2023
Type:
Article
Similar
MEDLINE
...
LILACS
LIS