Clinical efficacy and prognostic quality of neurointervention combined with alteplase in the treatment of acute ischemic stroke / 国际生物医学工程杂志

ABSTRACT

Objective:To study the clinical efficacy and prognostic quality of neurointervention combined with alteplase in the treatment of acute ischemic stroke.Methods:Ninety-two patients with acute ischemic stroke admitted to the First People's Hospital of Bijie City from February 2019 to December 2020 were selected and divided into the control group and the observation group using the random number method, with 46 cases in each group. Patients in both groups received conventional treatment with intravenous thrombolytic therapy with alteplase, and on this basis, patients in the observation group received neurointerventional treatment. The overall efficiency, national institutes of health stroke scale (NIHSS) score, modified Thrombolysis in cerebral infarction classification (mTICI) score, modified rankin scale (mRS) score, complication rate, and prognostic indexes of patients in both groups were compared after the treatment.Results:The total treatment efficiency of patients in the observation group was 93.48%, which was significantly higher than that of 76.09% in the control group ( P<0.05). The NIHSS scores of both groups were significantly lower than those of the same period before treatment at 1 and 7 days and 1 and 3 months after the treatment (all P<0.05), and the NIHSS scores of the observation group were significantly lower than those of the control group at the same period ( P<0.01). The proportions of mTICI grades < grade 2 and mRS scores in the observation group were significantly lower than those in the control group after treatment(all P<0.05). The overall complication rate of patients in the observation group was significantly lower than that of the control group( P<0.05), and the re-infarction rate of patients in the observation group was significantly lower than that of the control group ( P<0.05). Conclusions:For acute ischemic stroke, neurointervention combined with alteplase is effective, can reduce the risk of complications, and improve the quality of the patient's prognosis, and therefore deserves to be promoted in clinical practice.