The Study in Vitamin D Concentration in the Blood for Infants with High Level of Alkaline Phosphatase / 고신대학교의과대학학술지
Kosin Medical Journal
;
: 17-24, 2012.
Article
in Korean
| WPRIM
| ID: wpr-98971
ABSTRACT
OBJECTIVES:
Nowadays most infants on exclusively breast feeding have vitamin D deficiency due to the increase of breast feeding. However, domestic research lacks appropriate materials. Therefore, we researched practical clinical aspects of vitamin D deficiency related to breast milk feeding for infants who have a high amount of alkaline phosphatase (> 500 IU/L).METHODS:
The subjects of the study were 31 infants with high alkaline phosphatase level. We tested with 25-hydroxycholecalciferol (25-OHD3), parathyroid hormone, calcium, ionized calcium, phosphorus in their blood and with a wrist x-ray. Then, we divided them into two groups of breast feeding and formula feeding and compared the results.RESULTS:
Eighteen infants (58%) out of 31 infants that have high alkaline phosphatase were vitamin D insufficiency or deficiency, and 16 (100%) breast feeding infants of them showed vitamin D deficiency or insufficiency. However, only 2 (13%) of 15 formula feeding infants were at insufficiency. There was a correlation between alkaline phosphatase and 25-OHD3 concentration in multiple regression analysis, but no correlation in other variables was found in group of breast milk feeding infants. There was neither correlation between vitamin D concentration and alkaline phosphatase nor other correlated variables in the group of formula milk feeding infants.CONCLUSIONS:
In this study, there was a high probability of vitamin D deficiency in the breast feeding infants with a high alkaline phosphatase level. Therefore, it is considered to be worth utilizing alkaline phosphatase as a screening test for vitamin D deficiency or rickets for breast feeding infants.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parathyroid Hormone
/
Phosphorus
/
Rickets
/
Vitamin D
/
Vitamin D Deficiency
/
Vitamins
/
Wrist
/
Breast Feeding
/
Calcifediol
/
Mass Screening
Type of study:
Prognostic study
/
Screening study
Limits:
Humans
/
Infant
Language:
Korean
Journal:
Kosin Medical Journal
Year:
2012
Type:
Article
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