Anti-hyperlipidemic effect of soybean extract fermented by Bacillus subtilis MORI in db/db mice / 한국실험동물학회지
Laboratory Animal Research
;
: 123-129, 2012.
Article
in English
| WPRIM
| ID: wpr-98978
ABSTRACT
The purpose of this study was to investigate the anti-hyperlipidemic effect of soy bean extract solution fermented by Bacillus subtilis MORI (BTD-1E) in obese db/db mice. Eight-week-old male db/db mice were administered 33.3 mg/kg BTD-1E solution orally once a day for four weeks. The BTD-1E group showed significantly lower body weight compared with the db control group (P<0.05). The BTD-1E group showed significantly lower serum total cholesterol and LDL cholesterol levels compared with the db control group, respectively (P<0.05, P<0.01). The BTD-1E group showed significantly decreased liver weight relative to final body weight compared with the db control group (P<0.01). After four weeks of BTD-1E administration, lipid droplets in the liver were apparently decreased in the BTD-1E group compared to the db control group. In summary, our results suggest that BTD-1E has an anti-hyperlipidemic effect in the obese mouse model.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Glycine max
/
Bacillus
/
Bacillus subtilis
/
Body Weight
/
Cholesterol
/
1-Deoxynojirimycin
/
Cholesterol, LDL
/
Liver
/
Mice, Obese
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
Laboratory Animal Research
Year:
2012
Type:
Article
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