Historical control data from 13-week repeated toxicity studies in Crj:CD (SD) rats / 한국실험동물학회지
Laboratory Animal Research
;
: 115-121, 2012.
Article
in English
| WPRIM
| ID: wpr-98979
ABSTRACT
Reference ranges of standard experimental parameters are useful for comparisons in toxicology. The aim of this study was to collect data from 13-week repeated toxicity studies in CrlCD (SD) rats, a strain widely used for toxicity and efficacy research, for establishing domestic reference values. Data on body weight, food consumption; urinalysis, hematological, and blood biochemical parameters; and organ weights were collected from 11 toxicity studies in 220 CrlCD (SD) rats (110 males and 110 females). The studies had been performed at a single testing facility over the last 5 years and involved animals sourced from a single breeder. The findings were collated as means, standard deviations, percentages, and ranges. Urine volume, uterus weight, eosinophil, and basophil counts, and triglyceride, total bilirubin, and gamma-glutamyl transpeptidase levels showed standard deviations of 30% or more. These historical control data would help to interpret the effects of test substances in routine toxicity and efficacy studies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organ Size
/
Reference Values
/
Sprains and Strains
/
Toxicology
/
Uterus
/
Basophils
/
Bilirubin
/
Body Weight
/
Urinalysis
/
Eosinophils
Limits:
Animals
/
Humans
/
Male
Language:
English
Journal:
Laboratory Animal Research
Year:
2012
Type:
Article
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