Biomarkers and clinical significance of pediatric acute liver failure / 中国小儿急救医学

ABSTRACT

Pediatric acute liver failure(PALF)is a rare and life-threatening clinical syndrome caused by multiple etiologies with high mortality, rapid progress and bad prognosis.It′s crucial that how to identify liver failure early and evaluate the operation opportunity of liver transplantation accurately.Traditional serum biomarkers can be used to diagnose and evaluate the conditions of PALF, and they can also provide suggestions for treatment.In recent years, some new biomarkers of PALF have been emerged.This review summarized the traditional biomarkers and new biomarkers according to liver′s biological functions, aiming to improve the ability of clinicians to diagnose and treat PALF.