Progress on the mechanism of nuclear factor E2-related factor 2 activation mediating anti-sepsis cell-free hemoglobin oxidative stress / 中国小儿急救医学

ABSTRACT

Cell-free hemoglobin refers to the rupture of erythrocyte membrane due to instability of erythrocyte membrane caused by various causes, and hemoglobin is released free in the plasma.High concentration of plasma cell-free hemoglobin can cause intracellulariron ion deposition, oxidative damage, damage of lung, kidney and other related tissue, and seriously affect the treatment and prognosis of patients with sepsis.Nuclear factor E2-related factor 2(NRF2) as an antioxidant cytokine at the same time, plays important roles in the process of adjusting the resistance to oxidative stress, but the mechanism is not thorough.This review summarized the sepsis cell-free hemoglobin production, metabolism, and the activation of NRF2 and antioxidant mechanisms, to provide reference for further research.