Promoter -202 A/C Polymorphism of Insulin-like Growth Factor Binding Protein-3 Gene and Non-small Cell Lung Cancer Risk / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
;
: 359-366, 2005.
Article
in English
| WPRIM
| ID: wpr-99077
ABSTRACT
BACKGROUND:
IGFBP-3 inhibits the mitogenic and anti-apoptotic activity of IGF by blocking the binding of IGF to its receptor. However, under certain circumstances, IGFBP- 3 can enhance the activity of IGF by protecting IGF from its degradation. More than half of the inter- individual variations in IGFBP-3 levels are known to be genetically determined by the polymorphism at -202 locus of IGFBP-3 gene.METHOD:
We attempted to ascertain whether A-202C poly?morphic variation of IGFBP-3 gene constitutes a risk factor for non-small cell lung cancer (NSCLC), using PCR-restriction fragment length polymorphism (RFLP). Our study included 104 NSCLC patients and 104 age-, gender-, and smoking status-matched control subjects.RESULT:
In the 104 NSCLC subjects, the genotypic freque?ncies at the -202 site were as follows AA = 67 (64.4%), AC = 35 (33.7%), and CC = 2 (1.9%). We did detect significant differences in the genotypic distribution between the NSCLC and the control subjects (pAC>CC). Using CC genotype as a reference, the odds ratio (OR) for the subjects with AC genotype was 2.60 (95% CI 0.89 - 8.60), and the OR associated with AA genotype was 5.89 (95% CI 1.92 - 21.16).CONCLUSION:
These results indicate that the dysregulation of IGF axis should now be considered as another important risk factor for NSCLC, and a potential target for novel antineoplastic therapies and/or preventative strategies in high-risk groups.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Smoke
/
Axis, Cervical Vertebra
/
Smoking
/
Odds Ratio
/
Risk Factors
/
Carcinoma, Non-Small-Cell Lung
/
Insulin-Like Growth Factor Binding Protein 3
/
Genotype
Type of study:
Etiology study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Tuberculosis and Respiratory Diseases
Year:
2005
Type:
Article
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