The Clinical Effects of Perindopril(Acertil(R)) on Hypertensive Patients
Korean Circulation Journal
;
: 826-836, 1993.
Article
in Korean
| WPRIM
| ID: wpr-99196
ABSTRACT
BACKGROUND:
Perindopril. a new second-generation angiotensin converting enzyme inhibitor developed by Servier Research, was administered in essential hypertensive patients in order to observe the clinical effects.METHOD:
The changes of blood pressure, heart rate, quality of life, clinical laboratory examinations, side effects, electrocardiogram and echocardiographic left ventricular mass were evaluated before and after 4-12mg of perindopril 12 weeks' administration in 25 essential hypertensive patients(mild 10, moderate 8, severe 5, very severe 2 male 7, female 18 ; mean age 53.1+/-8.9 years).RESULT:
1) After treatment with perindopril alone, blood pressures were lowered markedly in 17(68%), moderately in 5(20%) and mildly in 2(8%) cases. The average of blood pressures of 25 subjects were systolic 173.1+/-22.8mmHg and diastolic 105.9+/-9.5mmHg before treatment, which were lowered to 125.2+/-14.9mmHg and 83.2+/-9.0mmHg respectively after 12 weeks(p<0.0001). 2) Quality of Life improved markedly in 11(44%) and slightly in 9(36%) cases after perindopril administration. 3) On electrocardiographic follow-up study, three out of five left ventricular hypertrophy with strain, seven out of 13 left ventricular hypertrophy, two out of three ST segment and T wave change and two sinus tachycardia were improved. Echocardiographic left ventricular mass was reduced significantly form 249.4+/-72.7g to 202.9 56.3g after 12 weeks perindopril treatment(p<0.0001). 4) Side effects were 5 cases of dry cough and 3 facial flushing. 5) Final Assessment of perindopril effect including hypotensive effect, quality of life, left ventricular mass regression and side effect showed very useful in 16(64%) and useful in 6(24%) out of 25 subjects.CONCLUSION:
Perindopril may be an effective initial single antihypertensive agent for the treatment of varying degree of hypertension, especially with left ventricular hypertrophy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Quality of Life
/
Blood Pressure
/
Tachycardia, Sinus
/
Echocardiography
/
Follow-Up Studies
/
Hypertrophy, Left Ventricular
/
Peptidyl-Dipeptidase A
/
Cough
/
Perindopril
/
Electrocardiography
Type of study:
Observational study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Language:
Korean
Journal:
Korean Circulation Journal
Year:
1993
Type:
Article
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