Further Characterization of Activin A-induced IgA Response in Murine B Lymphocytes
Immune Network
;
: 133-137, 2009.
Article
in English
| WPRIM
| ID: wpr-99214
ABSTRACT
We have recently shown that activin A, a member of TGF-beta superfamily, stimulates mouse B cells to express IgA isotype but other isotypes. In the present study, we further characterized effects of activin A on B cell growth and IgA expression. We found that activin A did not have effect on LPS-stimulated cell viability. In parallel, CFSE staining analysis revealed that activin A did not alter cell division. An increase of IgA secretion by activin A was completely abrogated by anti-activin A Ab but not by anti-TGFbeta1 Ab. In the same conditions, no other isotypes are significantly affected by each antibody treatment. Finally, activin A, as similar to TGF-beta1, increased IgA secretion by mesenteric lymph node cells. These results suggest that activin A can specifically stimulate IgA response, independent of TGF-beta in the gut.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Succinimides
/
Immunoglobulin A
/
B-Lymphocytes
/
Cell Division
/
Cell Survival
/
Transforming Growth Factor beta
/
Activins
/
Transforming Growth Factor beta1
/
Fluoresceins
/
Lymph Nodes
Limits:
Animals
Language:
English
Journal:
Immune Network
Year:
2009
Type:
Article
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